Sodium Hydroxide → 5-Acetyl-2-isopropoxy-benzoic acid

HRID 1820816노트

반응식

HRID 1820816 반응식
C[O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([C:10](=[O:12])[CH3:11])[CH:7]=[CH:6][C:5]=1[O:13][CH:14]([CH3:16])[CH3:15].[OH-].[Na+]>C1COCC1>[C:10]([C:8]1[CH:7]=[CH:6][C:5]([O:13][CH:14]([CH3:16])[CH3:15])=[C:4]([CH:9]=1)[C:3]([OH:17])=[O:2])(=[O:12])[CH3:11]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 690374735-Acetyl-2-isopropoxy-benzoic acid methyl ester

생성물 1

HCID 690386975-Acetyl-2-isopropoxy-benzoic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
80 °C

실험 절차

To 25.8 mmol 5-acetyl-2-isopropoxy-benzoic acid methyl ester in 100 ml THF was added 400 mmol 2 M aq NaOH, and the mixture was heated at 80° C. for 2 h. The mixture was then cooled to RT and extracted twice with ether. The aqueous phase was acidified with 15% aq hydrochloric acid and extracted 3 times with ethyl acetate. The combined organic phases were dried with Na2SO4. Evaporation in vacuo followed by trituration in ether afforded the title compound. MS (m/e): 221.2 ([M−H]−, 100%)

후처리

  1. temperatureThe mixture was then cooled to RT
  2. extractionextracted twice with ether
  3. extractionextracted 3 times with ethyl acetate
  4. dry with materialThe combined organic phases were dried with Na2SO4
  5. customEvaporation in vacuo

출처 및 근거

ORD 기록
ord-9dc86f791ac4419089fdb51d3d426125
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07605163B2

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