反应详情

温度

60 °C

To 2.5 mmol 2-(4-methoxy-benzyloxy)-5-sulfamoyl-benzoic acid methyl ester in 6 ml THF was added 5 mmol 2 M aq NaOH, and the mixture was heated at 60° C. for 30 min. The mixture was then cooled to RT and extracted twice with ethyl acetate. The aqueous phase was acidified to pH 1 with 5 M aq HCl and extracted with ethyl acetate. The combined organic phases were washed with saturated aq NaCl and dried with Na2SO4. Evaporation in vacuo afforded the title compound. MS (m/e): 336.1 ([M−H]−, 100%)

1. temperatureThe mixture was then cooled to RT
2. extractionextracted twice with ethyl acetate
3. extractionextracted with ethyl acetate
4. washThe combined organic phases were washed with saturated aq NaCl
5. dry with materialdried with Na2SO4
6. customEvaporation in vacuo