反应详情

7.80 g (27.8 mmol) of 4-(2-bromoethoxy)-3-chloronitrobenzene (III.1.a) and 10.1 mL (84.0 mmol) of 4-methylpiperidine is dissolved in 100 mL of methylene chloride and stirred for 12 hours at ambient temperature. Then the mixture is filtered through 400 g of aluminum oxide (activity 2-3) with methylene chloride/methanol 49:1 as eluant. Yield: 6.9 g (83% of theory); Rf value: 0.50 (aluminum oxide, petroleum ether/ethyl acetate=3:1); C14H19ClN2O3; EII mass spectrum: m/z=299/301 [M+H]+.

1. filtrationThen the mixture is filtered through 400 g of aluminum oxide (activity 2-3) with methylene chloride/methanol 49:1 as eluant