反应详情

2.00 g (7.79 mmol) of [2-(2-chloro-4-nitrophenyl)ethyl]diethylamine (VI.1.c) is dissolved in 50 mL of THF and hydrogenated for 2.5 hours at ambient temperature at a pressure of 25 psi with hydrogen and 0.8 g of Raney nickel as catalyst. Then the catalyst is filtered off and the solvent is eliminated. Yield: 1.80 g (100% of theory); Rf value: 0.45 (Alox, petroleum ether/ethyl acetate=1:1); C12H19ClN2; EII mass spectrum: m/z=227/229 [M+H]+.

1. filtrationThen the catalyst is filtered off