Isopropanol → 2-Isopropoxypyrimidine

HRID 1821074Notes

Reaction equation

HRID 1821074 reaction equation
Cl[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.C(NC(C)C)(C)C.[CH:15]([OH:18])([CH3:17])[CH3:16]>>[CH:15]([O:18][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1)([CH3:17])[CH3:16]

Participants

4

Reactant 3

HCID 3776IsopropanolHCID 7912DiisopropylamineHCID 744042-Chloropyrimidine

Product 1

HCID 221388532-Isopropoxypyrimidine

Conditions

Temperature
130 °C

Procedure

A 2-chloropyrimidine was dissolved in isopropyl alcohol to which was added diisopropylamine. The reaction was heated in a sealed tube for ten days at 130° C. The cooled reaction mixture was concentrated, and the product purified via silica gel column chromatography to yield the 2-isopropoxypyrimidine.

Workup

  1. customThe cooled reaction mixture
  2. concentrationwas concentrated
  3. customthe product purified via silica gel column chromatography

Sources & evidence

ORD record
ord-6a940d8d587c4f23ab06fbf14bca96dc
Source dataset
uspto-grants-2009_10
Patent number
US07605166B2

Reaction notes

Loading…