反应详情

To a solution of the crude mixture of 4-(4-oxo-cyclohex-1-enyl)-benzonitrile and 4-(4-oxo-cyclohex-1-enyl)-benzonitrile prepared above in step c (36.6 mmol) in EtOAc (120 mL) was added 10% Pd—C (900 mg) and the reaction was degassed (3× vacuum and H2). After being stirred 7 hours under H2 atmosphere, additional 10% Pd—C (500 mg) was added and the resulting reaction was stirred for an additional 12 h under H2 atmosphere. The catalyst was removed by filtration through Celite and the filtrate was concentrated under reduced pressure to give 4-(4-oxo-cyclohexyl)-benzonitrile as a white solid. The product was used for next step without further purification.

1. customthe reaction was degassed (3× vacuum and H2)
2. additionadditional 10% Pd—C (500 mg) was added
3. customthe resulting reaction
4. stirringwas stirred for an additional 12 h under H2 atmosphere
5. customThe catalyst was removed by filtration through Celite
6. concentrationthe filtrate was concentrated under reduced pressure