Dimethylamine → HCID 58980060, compound

HRID 1821177Notes

Reaction equation

[CH2:1]([N:3]1[CH:7]=[C:6]([C:8]2[C:13]([CH3:14])=[CH:12][N:11]=[C:10]3[NH:15][CH:16]=[CH:17][C:9]=23)[C:5]([C:18]2[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=2)=[N:4]1)[CH3:2].[CH3:25][NH:26][CH3:27].[O:28]1[CH2:32]CCC1>>[CH2:1]([N:3]1[CH:7]=[C:6]([C:8]2[C:13]([CH3:14])=[CH:12][N:11]=[C:10]3[NH:15][CH:16]=[CH:17][C:9]=23)[C:5]([C:18]2[CH:24]=[CH:23][C:21]([NH:22][C:32](=[O:28])[N:26]([CH3:27])[CH3:25])=[CH:20][CH:19]=2)=[N:4]1)[CH3:2]

Participants

Reactant 3

HCID 674Dimethylamine

HCID 8028Tetrahydrofuran

HCID 68999642HCID 68999642, compound

Product 1

HCID 58980060HCID 58980060, compound

Procedure

Following the procedure described in Example 5a with 4-[1-ethyl-4-(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]aniline and 2M dimethylamine in tetrahydrofuran afforded the title compound. ESMS[M+H]+: 389.4

Sources & evidence

ORD record: ord-8d0f649ad563474a8aad4b919b9d128d
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07605266B2

Reaction notes

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