Dimethylamine → N'-[4-(4-bromo-1-ethyl-1H-pyrazol-3-yl)phenyl]-N,N-dimethylurea

HRID 1821271Notes

Reaction equation

[Br:1][C:2]1[C:3]([C:9]2[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][CH:10]=2)=[N:4][N:5]([CH2:7][CH3:8])[CH:6]=1.[CH3:16][NH:17][CH3:18].[O:19]1[CH2:23]CCC1>>[Br:1][C:2]1[C:3]([C:9]2[CH:15]=[CH:14][C:12]([NH:13][C:23](=[O:19])[N:17]([CH3:18])[CH3:16])=[CH:11][CH:10]=2)=[N:4][N:5]([CH2:7][CH3:8])[CH:6]=1

Participants

Reactant 3

HCID 674Dimethylamine

HCID 8028Tetrahydrofuran

HCID 68995309HCID 68995309, compound

Product 1

HCID 68999367N'-[4-(4-bromo-1-ethyl-1H-pyrazol-3-yl)phenyl]-N,N-dimethylurea

Procedure

Following the procedure described in Example 5a with 4-(4-bromo-1-ethyl-1H-pyrazol-3-yl)aniline and 2 M dimethylamine in tetrahydrofuran provided the title compound. ESMS [M+H]+: 337.2

Sources & evidence

ORD record: ord-f47282d53a0641ae92b60c990919334a
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07605266B2

Reaction notes

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