2-Amino-5-bromo-3-(hydroxymethyl)pyridine hydrobromide → 5-Bromo-3-(bromomethyl)pyridin-2-amine hydrobromide

Participants

Reaction Steps

A suspension of 2-amino-5-bromo-3-(hydroxymethyl)pyridine hydrobromide (289 g, 1.02 mole) in 48% aqueous HBr (2.9 L) was heated at reflux for 12 hrs. Complete solution occurred during heating. The reaction mixture was cooled and a crystalline precipitate formed. This was filtered and washed with ethyl acetate and air dried to give the title compound (305 g, 86%).

Provenance & Evidence