反应详情

A suspension of 2-amino-5-bromo-3-(hydroxymethyl)pyridine hydrobromide (289 g, 1.02 mole) in 48% aqueous HBr (2.9 L) was heated at reflux for 12 hrs. Complete solution occurred during heating. The reaction mixture was cooled and a crystalline precipitate formed. This was filtered and washed with ethyl acetate and air dried to give the title compound (305 g, 86%).

1. temperaturewas heated
2. temperatureat reflux for 12 hrs
3. temperatureduring heating
4. temperatureThe reaction mixture was cooled
5. customa crystalline precipitate formed
6. filtrationThis was filtered
7. washwashed with ethyl acetate and air
8. customdried