Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 69000719 | HCID 69000719 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 68999288 | HCID 68999288 | 85% |
Reaction Steps
Compound 97 (740 mg, 1.77 mmol) was dissolved in methanol (5.00 mL) and the solution was added with 2 mol/L aqueous sodium hydroxide solution (5.00 mL), followed by stirring at 40° C. for 1 hour. The reaction mixture was acidified by hydrochloric acid (6 mol/L) and the precipitated crystal was collected by filtration to obtain Compound 98 (603 mg, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07605272B2 |
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| Source dataset | uspto-grants-2009_10 |
|---|
| ORD ID | ord-851b0ff55e3a4414ab2e260928babec8 |
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| Source note | uspto-grants-2009_10 |
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