Hydrochloric Acid → HCID 68999288, compound

HRID 1821334Notes

Reaction equation

HRID 1821334 reaction equation
C[O:2][C:3](=[O:30])[C:4]1[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14][N:13]=2)=[C:6]([NH:21][C:22]([C:24]2[S:25][CH:26]=[CH:27][C:28]=2[CH3:29])=[O:23])[CH:5]=1.[OH-].[Na+].Cl>CO>[NH:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:12](/[CH:11]=[CH:10]/[C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:30])=[O:2])=[CH:5][C:6]=2[NH:21][C:22]([C:24]2[S:25][CH:26]=[CH:27][C:28]=2[CH3:29])=[O:23])=[N:13]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69000719HCID 69000719, compound

Product 1

HCID 68999288HCID 68999288, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
40 °C

Procedure

Compound 97 (740 mg, 1.77 mmol) was dissolved in methanol (5.00 mL) and the solution was added with 2 mol/L aqueous sodium hydroxide solution (5.00 mL), followed by stirring at 40° C. for 1 hour. The reaction mixture was acidified by hydrochloric acid (6 mol/L) and the precipitated crystal was collected by filtration to obtain Compound 98 (603 mg, 85%).

Workup

  1. filtrationthe precipitated crystal was collected by filtration

Sources & evidence

ORD record
ord-851b0ff55e3a4414ab2e260928babec8
Source dataset
uspto-grants-2009_10
Patent number
US07605272B2

Reaction notes

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