Methanol → HCID 68998791, compound

HRID 1821336Notes

Reaction equation

HRID 1821336 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6](/[CH:18]=[CH:19]/[C:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][N:21]=2)=[C:7]([NH:9][C:10]([C:12]2[S:13][CH:14]=[CH:15][C:16]=2[CH3:17])=[O:11])[CH:8]=1.S(=O)(=O)(O)O.[CH3:34]O>>[NH:22]1[C:23]2[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:20](/[CH:19]=[CH:18]/[C:6]2[CH:5]=[CH:4][C:3]([CH2:2][O:1][CH3:34])=[CH:8][C:7]=2[NH:9][C:10]([C:12]2[S:13][CH:14]=[CH:15][C:16]=2[CH3:17])=[O:11])=[N:21]1

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 66585324HCID 66585324, compound

Product 1

HCID 68998791HCID 68998791, compoundYield 61%

Procedure

To Compound 108 (50.0 mg, 0.13 mmol), methanol (1.00 mL) and sulfuric acid (0.07 mL, 1.30 mmol) were added and the mixture was reacted in a microwave reaction vessel at 100° C. for 5 minutes to obtain Compound 121 (31.6 mg, 61%).

Workup

  1. customthe mixture was reacted in a microwave reaction vessel at 100° C. for 5 minutes

Sources & evidence

ORD record
ord-438d53c3601449ebb4fa364848e83f94
Source dataset
uspto-grants-2009_10
Patent number
US07605272B2

Reaction notes

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