Water → HCID 86628205, compound

HRID 1821361Notes

Reaction equation

HRID 1821361 reaction equation
C([O:3][C:4]([C:6]1[S:10][C:9]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2/[CH:18]=[CH:19]/[C:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][N:21]=2)=[N:8][CH:7]=1)=[O:5])C.[OH-].[Na+].O>CO>[NH:22]1[C:23]2[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:20](/[CH:19]=[CH:18]/[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[NH:11][C:9]2[S:10][C:6]([C:4]([OH:5])=[O:3])=[CH:7][N:8]=2)=[N:21]1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 86628204HCID 86628204, compound

Product 1

HCID 86628205HCID 86628205, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

Compound 165 (0.02 g, 0.051 mmol) was dissolved in methanol (1.0 mL) and 1 mol/L aqueous sodium hydroxide solution (1.0 mol) was added thereto, followed by stirring at 60° C. for 3 hours. The reaction mixture was added with water, washed with ethyl acetate and the aqueous layer was neutralized using 6 mol/L hydrochloric acid. The precipitated solid was triturated in ethyl acetate to obtain Compound 166 (13 mg, 72%).

Workup

  1. washwashed with ethyl acetate
  2. customThe precipitated solid was triturated in ethyl acetate

Sources & evidence

ORD record
ord-29fe1937a8fe4c99a0d66eb62fa83dbd
Source dataset
uspto-grants-2009_10
Patent number
US07605272B2

Reaction notes

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