Water → HCID 86628205, compound

Participants

Reaction Conditions

Reaction Steps

Compound 165 (0.02 g, 0.051 mmol) was dissolved in methanol (1.0 mL) and 1 mol/L aqueous sodium hydroxide solution (1.0 mol) was added thereto, followed by stirring at 60° C. for 3 hours. The reaction mixture was added with water, washed with ethyl acetate and the aqueous layer was neutralized using 6 mol/L hydrochloric acid. The precipitated solid was triturated in ethyl acetate to obtain Compound 166 (13 mg, 72%).

Provenance & Evidence