Ammonia → HCID 86628207, compound

Participants

Reaction Steps

Compound 161 (0.40 g, 1.4 mmol) was added with ethanol (3.0 mL, 1.5 mmol) and ethyl bromopyruvate (0.10 mL, 0.8 mmol) and after heating under reflux for 18 hours, aqueous ammonia was added to stop the reaction. The precipitated crude product was collected by filtration and purified by silica gel column chromatography (hexane/ethyl acetate=4/1 to 1/2). Then, the product was triturated in ethyl acetate to obtain Compound 169 (41 mg, 17%).

Provenance & Evidence