Hydrochloric Acid → HCID 68998390, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (E)-4-[2-(1H-indazol-3-yl)vinyl]-3-nitrobenzoic acid methyl ester (1.0 g, 3.1 mmol) obtained in Step 1 of Example 217 in methanol (20 mL) was added with 2 mol/L aqueous sodium hydroxide solution (10 mL) and stirred at 60° C. for 1 hour. The reaction mixture was acidified by hydrochloric acid (6 mol/L) and the precipitated crystal was collected by filtration to obtain 4-[2-(1H-indazol-3-yl)vinyl]-3-nitrobenzoic acid.

Provenance & Evidence