Hydrochloric Acid → HCID 68998390, compound

HRID 1821415Notes

Reaction equation

HRID 1821415 reaction equation
C[O:2][C:3](=[O:24])[C:4]1[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14][N:13]=2)=[C:6]([N+:21]([O-:23])=[O:22])[CH:5]=1.[OH-].[Na+].Cl>CO>[NH:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:12]([CH:11]=[CH:10][C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:24])=[O:2])=[CH:5][C:6]=2[N+:21]([O-:23])=[O:22])=[N:13]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68999445HCID 68999445, compound

Product 1

HCID 68998390HCID 68998390, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A solution of (E)-4-[2-(1H-indazol-3-yl)vinyl]-3-nitrobenzoic acid methyl ester (1.0 g, 3.1 mmol) obtained in Step 1 of Example 217 in methanol (20 mL) was added with 2 mol/L aqueous sodium hydroxide solution (10 mL) and stirred at 60° C. for 1 hour. The reaction mixture was acidified by hydrochloric acid (6 mol/L) and the precipitated crystal was collected by filtration to obtain 4-[2-(1H-indazol-3-yl)vinyl]-3-nitrobenzoic acid.

Workup

  1. filtrationthe precipitated crystal was collected by filtration

Sources & evidence

ORD record
ord-9594c8972f13471ca545f7d58e62ff73
Source dataset
uspto-grants-2009_10
Patent number
US07605272B2

Reaction notes

Loading…