Hydrochloric Acid → HCID 69002355, compound

Participants

Reaction Steps

In a similar manner to Example 2, (E)-2-{2-[2-(1H-indazol-3-yl)vinyl]-5-(morpholin-4-ylcarbonyl)phenyl}-4-nitroisoindole-1,3-dione (0.30 g, 0.57 mmol) obtained in Step 2 was dissolved in ethanol (30 mL) and was reacted with tin (0.2 g, 1.7 mmol) and concentrated hydrochloric acid (7.0 mL) at room temperature to obtain Compound 288 (46 mg, 53%).

Provenance & Evidence