Hydrochloric Acid → HCID 69002355, compound

HRID 1821421Notes

Reaction equation

HRID 1821421 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](/[CH:10]=[CH:11]/[C:12]2[CH:17]=[CH:16][C:15]([C:18]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[O:19])=[CH:14][C:13]=2[N:26]2[C:34](=[O:35])[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][C:32]=3[N+:36]([O-])=O)[C:27]2=[O:39])=[N:2]1.[Sn].Cl>C(O)C>[NH2:36][C:32]1[CH:31]=[CH:30][CH:29]=[C:28]2[C:33]=1[C:34](=[O:35])[N:26]([C:13]1[CH:14]=[C:15]([C:18]([N:20]3[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)=[O:19])[CH:16]=[CH:17][C:12]=1/[CH:11]=[CH:10]/[C:3]1[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][N:2]=1)[C:27]2=[O:39]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5352426Tin atomHCID 68999703HCID 68999703, compound

Product 1

HCID 69002355HCID 69002355, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a similar manner to Example 2, (E)-2-{2-[2-(1H-indazol-3-yl)vinyl]-5-(morpholin-4-ylcarbonyl)phenyl}-4-nitroisoindole-1,3-dione (0.30 g, 0.57 mmol) obtained in Step 2 was dissolved in ethanol (30 mL) and was reacted with tin (0.2 g, 1.7 mmol) and concentrated hydrochloric acid (7.0 mL) at room temperature to obtain Compound 288 (46 mg, 53%).

Sources & evidence

ORD record
ord-6a2f4165a8f040b2abd99dc344c97353
Source dataset
uspto-grants-2009_10
Patent number
US07605272B2

Reaction notes

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