反应详情

温度

60 °C

A solution of methyl (E)-{4-[2-(1H-indazol-3-yl)vinyl]-2-methoxy-3-nitrophenoxy}acetate obtained in Step 2 in methanol (20 mL) was added with 2 mol/L aqueous sodium hydroxide solution (10 mL) and stirred at 60° C. for 1 hour. To the reaction mixture under ice-cooling, 2 mol/L hydrochloric acid was added to neutralize the mixture. The precipitated solid was collected by filtration to obtain (E)-{4-[2-(1H-indazol-3-yl)vinyl]-2-methoxy-3-nitrophenoxy}acetic acid (1.9 g, 100%).

1. temperatureTo the reaction mixture under ice-cooling
2. filtrationThe precipitated solid was collected by filtration