Sodium Iodide → HCID 58754200, compound

HRID 1821558Notes

Reaction equation

HRID 1821558 reaction equation
Br[CH2:2][C:3]([O:5][CH2:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH3:16])=[CH:9][C:8]=1[N+:17]([O-:19])=[O:18])=[O:4].[Na+].[I-:21]>CC(C)=O>[I:21][CH2:2][C:3]([O:5][CH2:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH3:16])=[CH:9][C:8]=1[N+:17]([O-:19])=[O:18])=[O:4]

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 860712194.5-Dimethoxy-2-nitrobenzyl 2-bromoacetate

Product 1

HCID 58754200HCID 58754200, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A 4.5-dimethoxy-2-nitrobenzyl 2-bromoacetate (100 mg, 0.3 mmol) was dissolved in acetone (2 ml) and NaI (50 mg, 0.33 mmol) was added. After stirring for two hours at room temperature, mixture was filtered, evaporated and purified by chromatography (Si-gel, CH2Cl2) to yield 4.5-dimethoxy-2-nitrobenzyl 2-iodoacetate (compound E (see FIG. 12c): P6—C1[X═I]) (97 mg, 85%).

Workup

  1. filtrationmixture was filtered
  2. customevaporated
  3. custompurified by chromatography (Si-gel, CH2Cl2)

Sources & evidence

ORD record
ord-cefcd9de71de413da73015fdaa715b58
Source dataset
uspto-grants-2009_10
Patent number
US07608582B2

Reaction notes

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