HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → 1,1-Dimethylethyl (2S)-2-[(methoxymethylamino)carbonyl]-1-pyrrolidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Reactant | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| Product | 1,1-Dimethylethyl (2S)-2-[(methoxymethylamino)carbonyl]-1-pyrrolidinecarboxylate | HCID 688298 | — |
Reaction Steps
Boc-Proline (2.00 g, 9.29 mmol) and N,O-Dimethylhydroxylaminehydrochloride (0.91 g, 9.29 mmol) were treated as described for 1 using NMM (2 ml, 18.4 mmol) and CAIBE (1.47 ml, 9.29 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608577B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-883185de49d24f678c08eca91d261b18 |
| Source note | uspto-grants-2009_10 |