Thiazole → HCID 10265907, compound

HRID 1821570Notes

Reaction equation

HRID 1821570 reaction equation
[C:1]([N:8]1[CH2:14][CH2:13][CH2:12][C@H:9]1[CH:10]=[O:11])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[S:15]1[CH:19]=[CH:18][N:17]=[CH:16]1.[Li]CCCC>>[S:15]1[CH:19]=[CH:18][N:17]=[C:16]1[CH:10]([OH:11])[C@@H:9]1[CH2:12][CH2:13][CH2:14][N:8]1[C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

4

Reactant 3

HCID 9256ThiazoleHCID 2734674tert-butyl (2S)-2-formylpyrrolidine-1-carboxylateHCID 178418339Butyllithium

Product 1

HCID 10265907HCID 10265907, compound

Procedure

31 (1.0 g, 5.02 mmol), thiazole (0.39 ml, 5.52 mmol), n-BuLi (1.6 M) (3.45 ml 5.52 mmol).

Sources & evidence

ORD record
ord-79df3c61e7374c08806b832c354bd737
Source dataset
uspto-grants-2009_10
Patent number
US07608577B2

Reaction notes

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