2-Bromopyridine → HCID 10084955, compound

HRID 1821572Notes

Reaction equation

HRID 1821572 reaction equation
[C:1]([N:8]1[CH2:14][CH2:13][CH2:12][C@H:9]1[CH:10]=[O:11])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].Br[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=1.[Li]CCCC>>[N:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[CH:10]([OH:11])[C@@H:9]1[CH2:12][CH2:13][CH2:14][N:8]1[C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

4

Reactant 3

HCID 79732-BromopyridineHCID 2734674tert-butyl (2S)-2-formylpyrrolidine-1-carboxylateHCID 178418339Butyllithium

Product 1

HCID 10084955HCID 10084955, compound

Procedure

31 (1.3 g, 6.54 mmol), 2-bromopyridine (0.70 ml, 7.19 mmol), n-BuLi (1.6M) (4.5 ml, 7.19 mmol).

Sources & evidence

ORD record
ord-5d3e478c6e78454aaea8e7e9f2b735bc
Source dataset
uspto-grants-2009_10
Patent number
US07608577B2

Reaction notes

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