1-Hydroxybenzotriazole → 2-[(Benzothiazol-2-yl)hydroxymethyl]-1-{N-[N-(tertbutyloxycarbonyl) (L)-Alanyl]-glycyl}-(2S)-pyrrolidin

HRID 1821575Notes

Reaction equation

HRID 1821575 reaction equation
Cl.[S:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH:11]([OH:17])[C@@H:12]1[CH2:16][CH2:15][CH2:14][NH:13]1.C1C=CC2N(O)N=NC=2C=1.[NH:28]([C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[C@H:29]([C:31]([NH:33][C@H:34]([C:38](O)=[O:39])C(C)C)=[O:32])[CH3:30]>>[S:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH:11]([OH:17])[C@@H:12]1[CH2:16][CH2:15][CH2:14][N:13]1[C:38](=[O:39])[CH2:34][NH:33][C:31](=[O:32])[C@H:29]([CH3:30])[NH:28][C:41]([O:43][C:44]([CH3:45])([CH3:47])[CH3:46])=[O:42]

Participants

4

Procedure

36 (0.43 g, 1.23 mmol), HOBt (0.183 g, 1.35 mmol), WSCD (0.259 g, 1.35 mmol), Boc-Ala-Val-OH (0.303 g, 1.23 mmol), TEA (0.172 ml, 1.54 mmol)

Sources & evidence

ORD record
ord-d46c878a0e1248edac960bbd7d324e5c
Source dataset
uspto-grants-2009_10
Patent number
US07608577B2

Reaction notes

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