HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → 2-[(Benzothiazol-2-yl)hydroxymethyl]-1-{N-[N-(tertbutyloxycarbonyl) (L)-Alanyl]-glycyl}-(2S)-pyrrolidin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl- | HCID 11460416 | — |
| Reactant | 2-[(Benzothiazol-2-yl)hydroxymethyl]-(2s)-pyrrolidine hydrochloride | HCID 69033602 | — |
| Product | 2-[(Benzothiazol-2-yl)hydroxymethyl]-1-{N-[N-(tertbutyloxycarbonyl) (L)-Alanyl]-glycyl}-(2S)-pyrrolidin | HCID 69032265 | — |
Reaction Steps
36 (0.43 g, 1.23 mmol), HOBt (0.183 g, 1.35 mmol), WSCD (0.259 g, 1.35 mmol), Boc-Ala-Val-OH (0.303 g, 1.23 mmol), TEA (0.172 ml, 1.54 mmol)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608577B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-d46c878a0e1248edac960bbd7d324e5c |
| Source note | uspto-grants-2009_10 |