HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 2-[([1,3]-Thiazol-2-yl)carbonyl]-1-{N-[N-(tertbutyloxycarbonyl)(L)-Alanyl]-(L)-Valinyl}-(2S)-pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-[([1,3]-Thiazol-2-yl)hydroxymethyl]-1-{N-[N-(tertbutyloxycarbonyl) (L)-Alanyl]-(L)-Valinyl}-(2S)-pyrrolidine | HCID 69030757 | — |
| Product | 2-[([1,3]-Thiazol-2-yl)carbonyl]-1-{N-[N-(tertbutyloxycarbonyl)(L)-Alanyl]-(L)-Valinyl}-(2S)-pyrrolidine | HCID 69031730 | — |
Reaction Steps
38 (0.15 g, 0.33 mmol), oxalylchloride (0.05 ml, 0.59 mmol), DMSO (0.06 ml, 0.82 mmol), TEA (0.12 ml, 1.32 mmol)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608577B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-a5cc804c415646dfb303873b3b7337ff |
| Source note | uspto-grants-2009_10 |