Dimethyl Sulfoxide → 2-[([1,3]-Thiazol-2-yl)carbonyl]-1-{N-[N-(tertbutyloxycarbonyl)(L)-Alanyl]-(L)-Valinyl}-(2S)-pyrrolidine
Reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([OH:31])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:30])[C@H:13]([CH:27]([CH3:29])[CH3:28])[NH:14][C:15](=[O:26])[C@H:16]([CH3:25])[NH:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19].C(Cl)(=O)C(Cl)=O.CS(C)=O>>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]([C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:30])[C@H:13]([CH:27]([CH3:29])[CH3:28])[NH:14][C:15](=[O:26])[C@H:16]([CH3:25])[NH:17][C:18]([O:20][C:21]([CH3:23])([CH3:24])[CH3:22])=[O:19])=[O:31]Participants
4
Reactant 3
Product 1
Procedure
38 (0.15 g, 0.33 mmol), oxalylchloride (0.05 ml, 0.59 mmol), DMSO (0.06 ml, 0.82 mmol), TEA (0.12 ml, 1.32 mmol)
Sources & evidence
- ORD record
- ord-a5cc804c415646dfb303873b3b7337ff
- Source dataset
- uspto-grants-2009_10
- Patent number
- US07608577B2
Reaction notes
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