Dimethyl Sulfoxide → 2-[(Benzothiazol-2-yl)carbonyl]-1-{N-[N-(tertbutyloxycarbonyl)-(L)-Alanyl]-(L)-Valinyl}-(2S)-pyrrolidine
Reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10]([OH:35])[C@@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:16](=[O:34])[C@H:17]([CH:31]([CH3:33])[CH3:32])[NH:18][C:19](=[O:30])[C@H:20]([CH3:29])[NH:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23].C(Cl)(=O)C(Cl)=O.CS(C)=O>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]([C@@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:16](=[O:34])[C@H:17]([CH:31]([CH3:33])[CH3:32])[NH:18][C:19](=[O:30])[C@H:20]([CH3:29])[NH:21][C:22]([O:24][C:25]([CH3:27])([CH3:28])[CH3:26])=[O:23])=[O:35]Participants
4
Reactant 3
Product 1
Procedure
39 (0.72 g, 0.14 mmol), oxalylchloride (0.221 ml, 2.57 mmol), DMSO (2.53 ml, 3.57 mmol), TEA (0.80 ml, 5.71 mmol)
Sources & evidence
- ORD record
- ord-0f4b742c7beb4ce18138fae5129c2cee
- Source dataset
- uspto-grants-2009_10
- Patent number
- US07608577B2
Reaction notes
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