2,2-Dimethyl-3-(piperidin-1-yl)propan-1-ol → [6-(2,2-Dimethyl-3-piperidin-1-yl-propoxy)-naphthalen-2-yl]-(4-methyl-piperidin-1-yl)-methanone

HRID 1821620Notes

Reaction equation

HRID 1821620 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([N:14]1[CH2:19][CH2:18][CH:17]([CH3:20])[CH2:16][CH2:15]1)=[O:13])[CH:6]=[CH:5]2.[CH3:21][C:22]([CH3:32])([CH2:25][N:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)[CH2:23]O>>[CH3:23][C:22]([CH3:32])([CH2:25][N:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)[CH2:21][O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([N:14]1[CH2:15][CH2:16][CH:17]([CH3:20])[CH2:18][CH2:19]1)=[O:13])[CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 2960142,2-Dimethyl-3-(piperidin-1-yl)propan-1-olHCID 58933892(6-Hydroxy-naphthalen-2-yl)-(4-methyl-piperidin-1-yl)-methanone2×

Product 1

HCID 69062749[6-(2,2-Dimethyl-3-piperidin-1-yl-propoxy)-naphthalen-2-yl]-(4-methyl-piperidin-1-yl)-methanone

Procedure

The title compound was synthesised from (6-hydroxy-naphthalen-2-yl)-(4-methyl-piperidin-1-yl)-methanone (intermediate B) and 2,2-dimethyl-3-piperidin-1-yl-propan-1-ol (commercially available) according to the procedure described for the synthesis of Example 1. MS (m/e): 423.1 (MH+, 100%)

Workup

  1. customdescribed for the synthesis of Example 1

Sources & evidence

ORD record
ord-e854fd8b90cd4d0cab66a561a98fef51
Source dataset
uspto-grants-2009_10
Patent number
US07608617B2

Reaction notes

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