4,6-dichloro-N-phenyl-1,3,5-triazin-2-amine → HCID 9945961, compound

HRID 1821631Notes

Reaction equation

HRID 1821631 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:3]=1.[CH2:16]1[O:25][C:24]2[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][C:18]=2[O:17]1>>[O:25]1[C:24]2[CH:23]=[CH:22][C:20]([NH:21][C:6]3[N:5]=[C:4]([NH:9][C:10]4[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=4)[N:3]=[C:2]([Cl:1])[N:7]=3)=[CH:19][C:18]=2[O:17][CH2:16]1

Participants

3

Reactant 2

HCID 167664,6-dichloro-N-phenyl-1,3,5-triazin-2-amineHCID 843101,3-Benzodioxol-5-amine

Product 1

HCID 9945961HCID 9945961, compoundYield 42%

Procedure

The reaction of 4,6-dichloro-N-phenyl-[1,3,5]triazine-2-amine with 3,4-methylenedioxyaniline using the method described for the synthesis of CT-32028 provided CT-32042 (51 mg, 42% yield). 1H NMR (d6-DMSO) δ 10.05-10.29 (m, 2H), 7.57-7.80 (m, 2H), 7.21-7.42 (m, 3H), 6.80-7.13 (m, 3H), 6.03 (s, 2H).

Workup

  1. customdescribed for the synthesis of CT-32028 provided CT-32042 (51 mg, 42% yield)

Sources & evidence

ORD record
ord-c8591c8a4e4c43de9b65ebdbb94f2f09
Source dataset
uspto-grants-2009_10
Patent number
US07608620B2

Reaction notes

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