反应详情

A solution of the aminonitrile 12 (19.89 g, 88 mmole) in absolute THF (160 ml) was added dropwise to a 1M solution of 4-fluorophenyl magnesium bromide in THF (220 ml, 220 mmole) under argon and while cooling with ice, and stirred for 20 hours at RT. To work up the reaction mixture saturated ammonium chloride solution (100 ml) and water (100 ml) were added while cooling with ice and the mixture was extracted with diethyl ether (3×100 ml). The organic phase was washed with water and saturated sodium chloride solution, dried (Na2SO4) and concentrated by evaporation.

1. temperaturewhile cooling with ice
2. additionwere added
3. temperaturewhile cooling with ice
4. extractionthe mixture was extracted with diethyl ether (3×100 ml)
5. washThe organic phase was washed with water and saturated sodium chloride solution
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated by evaporation