反应详情

A solution of the aminonitrile 12 (2.24 g, 10 mmole) in absolute THF (10 ml) was added dropwise to a 1M solution of thiophen-2-yl-magnesium bromide in THF (20 ml, 20 mmole) under argon and while cooling with ice, and stirred for 20 hours at RT. To work up the reaction mixture saturated ammonium chloride solution (10 ml) and water (10 ml) were added while cooling with ice and the mixture was extracted with diethyl ether (3×10 ml). The organic phase was washed with water and saturated sodium chloride solution, dried and concentrated by evaporation.

1. temperaturewhile cooling with ice
2. additionwere added
3. temperaturewhile cooling with ice
4. extractionthe mixture was extracted with diethyl ether (3×10 ml)
5. washThe organic phase was washed with water and saturated sodium chloride solution
6. customdried
7. concentrationconcentrated by evaporation