HCID 23013815, compound → Hydrochloric Acid

HRID 1821660Notes

Reaction equation

HRID 1821660 reaction equation
[Cl:1][C:2]1([Cl:15])[CH2:4][CH:3]1[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH2:12][O:13][CH3:14]>CO>[Cl:1][C:2]1([Cl:15])[CH2:4][CH:3]1[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH2:12][O:13][CH3:14].[ClH:1]

Participants

4

Reactant 1

HCID 23013815HCID 23013815, compound

Product 2

HCID 313Hydrochloric AcidHCID 23013815HCID 23013815, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In methanol (5 mL) was dissolved 203 mg (0.822 mmol) of 1-(2,2-dichlorocyclopropyl)-2-(methoxymethoxy)benzene obtained in (1), 0.1 mL of conc. hydrochloric acid was added to the solution, and the resulting mixture was stirred at 60° C. for 2 hours. After confirming disappearance of the starting materials by thin layer chromatography, the reaction mixture was poured into water, and extracted with ethyl acetate. The organic layers were combined, washed successively with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed to obtain 194 mg of a crude product of 2-(2,2-dichlorocyclopropyl)phenol.

Sources & evidence

ORD record
ord-f4a7b315d92f4b3e9d2bc066a355cff4
Source dataset
uspto-grants-2009_10
Patent number
US07608563B2

Reaction notes

Loading…