反应详情

In toluene (2 mL) was dissolved 123 mg (0.490 mmol) of 6-chloro-4-methoxy-3-(2-methylphenoxy)pyridazine obtained in Example 2 (1), 246 mg (0.776 mmol) of tributyl-(vinyl)tin, and then, 119 mg (0.103 mmol) of tetrakis(triphenylphosphine)palladium were successively added to the solution at room temperature, and the resulting mixture was refluxed for 3 hours. The reaction mixture was allowed to stand for cooling, ethyl acetate (5 mL), water (3 mL) and sodium fluoride were added to the mixture, and the resulting mixture was stirred for 30 minutes and allowed to stand at at room temperature overnight. The mixture was filtered through Celite, ethyl acetate was added to the filtrate, then the organic layer was separated and washed with brine. After drying over anhydrous sodium sulfate, the solvent was removed. The obtained residue was purified by silica gel column chromatography (eluted with hexane:ethyl acetate=1:2) to obtain 105 mg (0.434 mmol, Yield: 88.6%) of 4-methoxy-3-(2-methylphenoxy)-6-vinylpyridazine.

1. temperaturethe resulting mixture was refluxed for 3 hours
2. temperaturefor cooling
3. customto stand at at room temperature overnight
4. filtrationThe mixture was filtered through Celite, ethyl acetate
5. additionwas added to the filtrate
6. customthe organic layer was separated
7. washwashed with brine
8. dry with materialAfter drying over anhydrous sodium sulfate
9. customthe solvent was removed
10. customThe obtained residue was purified by silica gel column chromatography (eluted with hexane:ethyl acetate=1:2)