Sodium Hydroxide → HCID 22940115, compound

HRID 1821709Notes

Reaction equation

HRID 1821709 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([O:8][C:9]2[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][C:10]=2[CH:16]2[CH2:18][CH2:17]2)=[C:4]([OH:19])[CH:3]=1.[OH-].[Na+]>[Cl-].C([N+](CCCC)(CCCC)CCCC)CCC.C(O)C>[Cl:1][C:2]1[N:7]=[N:6][C:5]([O:8][C:9]2[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][C:10]=2[CH:16]2[CH2:18][CH2:17]2)=[C:4]([O-:19])[CH:3]=1.[CH2:9]([N+:6]([CH2:5][CH2:4][CH2:3][CH3:2])([CH2:5][CH2:4][CH2:3][CH3:2])[CH2:14][CH2:13][CH2:12][CH3:11])[CH2:10][CH2:16][CH3:17]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 178424441HCID 178424441, compound

Product 1

HCID 22940115HCID 22940115, compound

Reagents, catalysts & solvents 2

HCID 70681Tetrabutylammonium ChlorideCatalystHCID 702EthanolSolvent

Procedure

To an ethanol (2 mL) solution containing 105 mg (0.379 mmol) of 6-chloro-3-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinol were added 0.19 mL (0.38 mmol) of 2 mol/L aqueous sodium hydroxide solution, then, 106 mg (0.381 mmol) of tetrabutylammonium chloride, and the resulting mixture was stirred at 60° C. for 5 hours. The reaction mixture was allowed to stand at room temperature overnight, and the solid was removed by filtration. The filtrate was concentrated to obtain N,N,N-tributyl-1-butanaminium 6-chloro-3-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinolate (Compound No. 3798).

Workup

  1. customthe solid was removed by filtration
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-51997fcdc7bf4bc9807a6fe169614aef
Source dataset
uspto-grants-2009_10
Patent number
US07608563B2

Reaction notes

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