HCID 76852918, compound → HCID 68981209, compound

HRID 1821814Notes

Reaction equation

HRID 1821814 reaction equation
Cl[C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[CH:10]=[C:9]([C:11]([NH:13][CH:14]3[CH2:18][CH2:17][CH2:16][CH2:15]3)=[O:12])[NH:8][C:7]=12>C(O)C>[CH:14]1([NH:13][C:11]([C:9]2[NH:8][C:7]3=[CH:2][N:3]=[CH:4][CH:5]=[C:6]3[CH:10]=2)=[O:12])[CH2:15][CH2:16][CH2:17][CH2:18]1

Participants

3

Reactant 1

HCID 76852918HCID 76852918, compound

Product 1

HCID 68981209HCID 68981209, compoundYield 43%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-Cyclopentyl-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (20 mg, 43%) was prepared as an off-white solid following the procedure described for Example 27 using 7-chloro-N-cyclopentyl-1H-pyrrolo[2,3-c]pyridine-2-carboxamide and ethanol as a solvent: mp 220-224° C.; 1H NMR (300 MHz, CD3OD) δ1.22-2.18 (8H, m), 4.28-4.42 (1H, m), 7.27 (1H, s), 7-82 (1H, d, J=5.8 Hz), 8.15 (1H, d, J=5.8 Hz), 8.85 (1H, s); ESI MS m/z 230 [C13H15N3O+H]+; HPLC (Method A) >99% (AUC), tR=12.1 min.

Sources & evidence

ORD record
ord-3e9f039897a0467590d8997643a484f1
Source dataset
uspto-grants-2009_10
Patent number
US07608627B2

Reaction notes

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