HCID 57893495, compound → HCID 57893529, compound

HRID 1821839Notes

Reaction equation

HRID 1821839 reaction equation
Cl[C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[CH:10]=[C:9]([C:11]([N:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)=[O:12])[NH:8][C:7]=12>C(O)C>[N:13]1([C:11]([C:9]2[NH:8][C:7]3=[CH:2][N:3]=[CH:4][CH:5]=[C:6]3[CH:10]=2)=[O:12])[CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

3

Reactant 1

HCID 57893495HCID 57893495, compound

Product 1

HCID 57893529HCID 57893529, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(1-Pyrrolidinylcarbonyl)-1H-pyrrolo[2,3-c]pyridine (22 mg, 46%) was prepared as an off-white solid following the procedure described for Example 27 using 7-chloro-2-(1-pyrrolidinylcarbonyl)-1H-pyrrolo[2,3-c]pyridine (Example 13) and ethanol as a solvent: mp 260-275° C. dec.; 1H NMR (300 MHz, CD3OD) δ1.98-2.10 (4H, m), 3.66-3.71 (2H, m), 3.89-3.94 (2H, m), 7.10 (1H, s), 7.74 (1H, d, J=5.4 Hz), 8.13 (1H, d, J=5.7 Hz), 8.82 (1H, s); ESI MS m/z 216 [C12H13N3O+H]+; HPLC (Method A) 93.3% (AUC), tR=10.3 min.

Sources & evidence

ORD record
ord-307d60b6ed6046f6af46e645b4897b5b
Source dataset
uspto-grants-2009_10
Patent number
US07608627B2

Reaction notes

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