Trifluoroacetic acid → HCID 136386502, compound

HRID 1821863Notes

Reaction equation

HRID 1821863 reaction equation
[C:1]1([C:7](=[N:17][O:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[C:8]2[NH:16][C:11]3=[CH:12][N:13]=[CH:14][CH:15]=[C:10]3[CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C(O)=O>>[C:1]1([C:7](=[N:17][O:18][CH2:19][C:20]([OH:22])=[O:21])[C:8]2[NH:16][C:11]3=[CH:12][N:13]=[CH:14][CH:15]=[C:10]3[CH:9]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 136386498HCID 136386498, compound

Product 1

HCID 136386502HCID 136386502, compound

Procedure

[[[Phenyl(1H-pyrrolo[2,3-c]pyridin-2-yl)methylene]amino]oxy]acetic acid was prepared by treating tert-butyl[[[phenyl(1H-pyrrolo[2,3-c]pyridin-2-yl)methylene]amino]oxy]acetate (Example 58) (18 mg, 0.05 mmol) with trifluoroacetic acid (1 mL) as an off white solid after concentration: mp 68-73° C.; ESI MS m/z 296 [C16H13N3O3+H]+; HPLC (Method A) 98.9% (AUC), tR=15.7 min.

Workup

  1. concentrationafter concentration

Sources & evidence

ORD record
ord-15138875ff34488187a5bfe7a3251ec3
Source dataset
uspto-grants-2009_10
Patent number
US07608627B2

Reaction notes

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