Trifluoroacetic acid → HCID 12992898, compound

HRID 1821929Notes

Reaction equation

HRID 1821929 reaction equation
C([O:5][C:6]([C:8]1[N:9]([CH2:13][C:14](=[O:31])[CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])=[CH:19][CH:18]=2)[CH:10]=[CH:11][CH:12]=1)=[O:7])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH2:23]([C:20]1[CH:21]=[CH:22][C:17]([O:16][CH2:15][C:14](=[O:31])[CH2:13][N:9]2[CH:10]=[CH:11][CH:12]=[C:8]2[C:6]([OH:7])=[O:5])=[CH:18][CH:19]=1)[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 12992897tert-Butyl-1-[3-(4-octylphenoxy)-2-oxopropyl]pyrrole-2-carboxylate

Product 1

HCID 12992898HCID 12992898, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.045 g (0.105 mmol) tert-butyl-1-[3-(4-octylphenoxy)-2-oxopropyl]pyrrole-2-carboxylate is dissolved in 10 ml absolute dichloromethane and mixed with 0.900 g (7.89 mmol) trifluoroacetic acid. After stirring at room temperature for 1 hour, the batch is concentrated to dryness on the rotary evaporator. Two dissolutions in toluene and respective concentration on the rotary evaporator leave as a crude product a brownish solid which is recrystallized from methanol and some water drops and yields the product as a beige solid.

Workup

  1. concentrationthe batch is concentrated to dryness on the rotary evaporator
  2. concentrationTwo dissolutions in toluene and respective concentration
  3. customon the rotary evaporator
  4. customleave as a crude product a brownish solid which
  5. customis recrystallized from methanol

Sources & evidence

ORD record
ord-01f640f626d84393b4c7bd89a4b7009d
Source dataset
uspto-grants-2009_10
Patent number
US07608633B2

Reaction notes

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