反应详情

0.046 g (0.096 mmol) tert-butyl-1-[3-(4-octylphenoxy)-2-oxopropyl]indole-2-carboxylate is dissolved in 10 ml absolute dichloromethane and mixed with 1.49 g (13.6 mmol) trifluoroacetic acid. Having stirred at room temperature for 1½ hours, concentration to dryness is carried out on the rotary evaporator. Two dissolution steps in toluene and respective concentration on the rotary evaporator leave as a crude product a yellowish solid which is recrystallized from petroleum ether/ethyl acetate (67:33) and yields the product as a white solid.

1. concentrationconcentration to dryness
2. customis carried out on the rotary evaporator
3. dissolutionTwo dissolution steps in toluene
4. concentrationrespective concentration
5. customon the rotary evaporator
6. customleave as a crude product a yellowish solid which
7. customis recrystallized from petroleum ether/ethyl acetate (67:33)