反应详情

0.072 g (0.151 mmol) tert-butyl-1-[3-(4-octylphenoxy)-2-oxopropyl]indole-3-carboxylate is dissolved in 10 ml absolute dichloromethane and mixed with 1.56 g (13.7 mmol) trifluoroacetic acid. Having stirred at room temperature for 1 hour, concentration to dryness is carried out on the rotary evaporator. Two dissolution steps in toluene and respective concentration on the rotary evaporator leave as the crude product a reddish solid which is recrystallized from petroleum ether/ethyl acetate (67:33) and yields the product as a white solid.

1. concentrationconcentration to dryness
2. customis carried out on the rotary evaporator
3. dissolutionTwo dissolution steps in toluene
4. concentrationrespective concentration
5. customon the rotary evaporator
6. customleave as the crude product a reddish solid which
7. customis recrystallized from petroleum ether/ethyl acetate (67:33)