2,4,6-Trifluorobenzoyl chloride → HCID 69065181, compound

HRID 1822051Notes

Reaction equation

HRID 1822051 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([O:8][C:9]2[N:14]=[C:13]([NH2:15])[CH:12]=[CH:11][CH:10]=2)[CH2:4][CH2:3]1.[F:16][C:17]1[CH:25]=[C:24]([F:26])[CH:23]=[C:22]([F:27])[C:18]=1[C:19]([Cl:21])=[O:20]>>[ClH:21].[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([O:8][C:9]2[N:14]=[C:13]([NH:15][C:19](=[O:20])[C:18]3[C:22]([F:27])=[CH:23][C:24]([F:26])=[CH:25][C:17]=3[F:16])[CH:12]=[CH:11][CH:10]=2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 1448952,4,6-Trifluorobenzoyl chlorideHCID 187718666-(1-Methyl-piperidin-4-yloxy)-pyridin-2-ylamine

Product 1

HCID 69065181HCID 69065181, compoundYield 88%

Procedure

Using a method similar to example 154, using 6-(1-methyl-piperidin-4-yloxy)-pyridin-2-ylamine (preparation 60, 200 mg, 0.965 mmol) and 2,4,6-trifluorobenzoyl chloride (150 μL, 1.16 mmol) yields of the title compound (341 mg, 88%). Mass spectrum (ion spray): m/z 365.8 (M+1); Analysis calculated for C18H19N3O2ClF3. Theory: C, 53.81; H, 4.76; N, 10.46. Found: C, 53.74; H, 5.03; N, 10.43. mp=264-6° C.

Sources & evidence

ORD record
ord-f491975b001b454eb333369b5d03062f
Source dataset
uspto-grants-2009_10
Patent number
US07608629B2

Reaction notes

Loading…