2,4,6-Trifluorobenzoyl chloride → HCID 69065181, compound

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Reaction Steps

Using a method similar to example 154, using 6-(1-methyl-piperidin-4-yloxy)-pyridin-2-ylamine (preparation 60, 200 mg, 0.965 mmol) and 2,4,6-trifluorobenzoyl chloride (150 μL, 1.16 mmol) yields of the title compound (341 mg, 88%). Mass spectrum (ion spray): m/z 365.8 (M+1); Analysis calculated for C18H19N3O2ClF3. Theory: C, 53.81; H, 4.76; N, 10.46. Found: C, 53.74; H, 5.03; N, 10.43. mp=264-6° C.

Provenance & Evidence