Methanol → n-(3-Chloro-4-fluorophenyl)-n-(3-methoxybenzyl)alanine lithium salt

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	Tetrahydrofuran	HCID 8028	—
Reactant	Lithium hydroxide, monohydrate	HCID 168937	—
Reactant	methyl N-(3-chloro-4-fluorophenyl)-N-(3-methoxybenzyl)alaninate	HCID 68982423	—
Solvent	Water	HCID 962	—
Product	n-(3-Chloro-4-fluorophenyl)-n-(3-methoxybenzyl)alanine lithium salt	HCID 68983355	—

Reaction Steps

Methyl N-(3-chloro-4-fluorophenyl)-N-(3-methoxybenzyl)alaninate (6-1, 0.510 g, 1.450 mmol) in a 3:1:1 mixture of THF:MeOH:H2O (100 mL) was treated with LiOH hydrate (0.067 g, 1.595 mmol) then stirred 24 h. Upon completion, the reaction mixture was concentrated under vacuum to yield N-(3-chloro-4-fluorophenyl)-N-(3-methoxybenzyl)alanine lithium salt (6-2). MS 338.2 found 338.8 (M+H+) required.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07608739B2
Source dataset	uspto-grants-2009_10
ORD ID	ord-7e327a6b67e9485b8abb9aec42900f13
Source note	uspto-grants-2009_10