反应详情

A solution of ethyl 3-(pyridin-4-yl)propionate (17.14 g, 96 mmol; synthesized according to WO, A, 01/42244) in aqueous sodium hydroxide (2N, 100 ml) was heated under reflux for 1 hour, cooled, then adjusted pH 4 to 5 with conc. sulfuric acid, filtered to give precipitates which were washed with water, and then with hexane, and dried to afford 3-(pyridin-4-yl)propionic acid (10.15 g, 70%) as crystals.

1. temperatureunder reflux for 1 hour
2. temperaturecooled
3. filtrationfiltered
4. customto give
5. customprecipitates which
6. washwere washed with water
7. dry with materialwith hexane, and dried