Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → 3-(Pyridin-4-yl)propanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Ethyl isonicotinylacetate | HCID 12229233 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | 3-(Pyridin-4-yl)propanoic acid | HCID 233243 | 70% |
반응 단계
A solution of ethyl 3-(pyridin-4-yl)propionate (17.14 g, 96 mmol; synthesized according to WO, A, 01/42244) in aqueous sodium hydroxide (2N, 100 ml) was heated under reflux for 1 hour, cooled, then adjusted pH 4 to 5 with conc. sulfuric acid, filtered to give precipitates which were washed with water, and then with hexane, and dried to afford 3-(pyridin-4-yl)propionic acid (10.15 g, 70%) as crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07608716B2 |
| 출처 데이터셋 | uspto-grants-2009_10 |
| ORD ID | ord-97dab19923534c1195d444cc8b61ce7a |
| 출처 메모 | uspto-grants-2009_10 |