4-Chlorophenol → HCID 57894156, compound

HRID 1822262Notes

Reaction equation

HRID 1822262 reaction equation
C[O:2][C:3](=[O:21])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15](Br)[CH:14]=2)=[CH:8][C:7]=1[CH3:20].[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1>>[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][C:15]2[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=2)[O:12][C:9]2[CH:10]=[CH:11][C:6]([CH2:5][CH2:4][C:3]([OH:2])=[O:21])=[C:7]([CH3:20])[CH:8]=2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 46844-ChlorophenolHCID 578941923-[4-(3-Bromo-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester

Product 1

HCID 57894156HCID 57894156, compound

Procedure

The title compound is prepared by reacting the compound of 3-[4-(3-bromo-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester with 4-chlorophenol as in Example 18 to afford 0.019 g (9%). 1H NMR (400 MHz, CDCl3); HRMS (ES+) m/z exact mass calculated for C22H19O4Cl 383.1050, found 383.1033 (M+1).

Workup

  1. customto afford 0.019 g (9%)

Sources & evidence

ORD record
ord-26c6e1cea75e42ab9dedd19959863c10
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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