HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-phenoxyphenol → 3-{4-[3-(4-Chloro-2-phenoxy-phenoxy)-5-fluoro-phenoxy]-2-methyl-phenyl}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-phenoxyphenol | HCID 12774295 | — |
| Reactant | 3-[4-(3-Bromo-5-fluoro-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester | HCID 57894233 | — |
| Product | 3-{4-[3-(4-Chloro-2-phenoxy-phenoxy)-5-fluoro-phenoxy]-2-methyl-phenyl}-propionic acid | HCID 11283285 | — |
Reaction Steps
The title compound is prepared by reacting the compound of 3-[4-(3-bromo-5-fluoro-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester with 4-chloro-2-phenoxy-phenol as in Example 18 to afford 0.118 g (22%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calculated for C28H22O5ClF 492, found 493 and 495 (M+1 and M+3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608639B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-3e79491bc1c6428bbd2701e83cb6bc7b |
| Source note | uspto-grants-2009_10 |